| Registro completo |
| Provedor de dados: |
Nature Precedings
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| País: |
United Kingdom
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| Título: |
Ajuvant effect of a Synthetic Aluminium - Magnesium Silicate on chloroquine phosphate, against Plasmodium berghei.
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| Autores: |
madike ezeibe
obianuju obianuju Okoroafor
nnenna elendu-eleke
Augustine Ngene
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| Data: |
2012-01-02
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| Ano: |
2012
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| Palavras-chave: |
Pharmacology
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| Resumo: |
Abstract effect of a synthetic Aluminium - Magnesium Silicate (AMS) on antiplasmodial activity of chloroquine was tested. Plasmodium berghei-infected mice were treated with 7 mg/kg, 5 mg/kg and 3 mg/kg chloroquine, respectively. The two subgroups in each experiment were treated with chloroquine alone and with chloroquine in AMS respectively. Parasitaemia (%) of the group treated with 7 mg/kg was higher than that of the control. At 5 mg/kg, chloroquine treatment significantly reduced parasitaemia from 3.60 to 2.46 (P =0.01). Incorporating chloroquine in AMS significantly improved its ability to reduce P. berghei parasitaemia at 5 mgkg and at 3 mg/kg, from 2.46 0.21 to 1.57 0.25 (P = 0.01) and from 3.82 0.06 to 2.12 0.08 (P =0.01 ). It also increased mortality of mice treated at 7 mg/kg from 20 to 80 %.
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| Tipo: |
Manuscript
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| Identificador: |
http://precedings.nature.com/documents/6749/version/1
oai:nature.com:10101/npre.2012.6749.1
http://hdl.handle.net/10101/npre.2012.6749.1
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| Fonte: |
Nature Precedings
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| Direitos: |
Creative Commons Attribution 3.0 License
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